过刊浏览-菌物学报杂志社

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多组学驱动食用菌遗传育种研究范式转变

韩蓓, 赵瑞琳
中国是食用菌大国，为了进一步增强产业创新能力，加大食用菌的基础研究是关键突破口。近年来随着生物技术的快速发展，组学驱动食用菌研究从表型描述向系统性机制解析转变。应用单一组学技术目前已在食用菌遗传基础、基因调控、蛋白动态、代谢通路及表型分析等分子调控研究取得了广泛进展，但应用多组学联用整合分析才能解决单一组学数据片面化、碎片化的问题，所以多组学技术逐渐成为食用菌遗传育种研究范式转变的核心驱动力。虽然目前研究仍面临数据质量、功能验证、计算资源、整合复杂性等挑战，未来仍需聚焦底层技术革新、人工智能驱动、跨尺度整合、资源平台建设等，继续推动多组学深度整合与创新应用，助力食用菌产业高质量发展，以满足粮食安全与大健康需求。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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寄生鳞翅目幼虫的线虫草属一新种: 羽束梗孢状线虫草

常衬心, 张忠霞, 邓丽萍, 梁建东, 俞琦, 代永东
线虫草属Ophiocordyceps是虫草类真菌中一个物种丰富、分布广泛、寄主多样的重要大属，目前已报道物种超过400种。中国西南的云南横断山区是生物多样性热点地区，也是该属多样性的重要集中分布区。本研究在云南兰坪县采集到一线虫草标本，结合形态特征、ITS序列及联合5基因(nrSSU、nrLSU、tef-1α、rpb1和rpb2)系统发育分析，确定该物种为线虫草属一新种，命名为羽束梗孢状线虫草Ophiocordyceps paraisarioidea sp. nov.。该种子座结构容易被误认为是Paraisaria属物种，但表现出更深的子座色泽、顶端具小突起的球形可孕部，以及不断裂的多隔梭形子囊孢子。5基因系统发育结果显示，该种与虫根线虫草Ophiocordyceps entomorrhiza 聚为一支，位于线虫草属的进化枝基部(basal clade)，但二者在形态和寄主选择上存在显著差异：O. paraisarioidea 子座深棕色，顶端灰白，寄主为鳞翅目蛾类幼虫；而 O. entomorrhiza 子座偏黑，寄主为鞘翅目步甲属幼虫及成虫。形态比较和5基因系统发育结果表明本文报道的O. paraisarioidea 是线虫草属进化枝基部类群的一新物种，丰富了该分支物种多样性。此外，O. paraisarioidea 以鳞翅目昆虫为寄主的特征，拓宽了线虫草属基部类群物种寄主范畴，提示“线虫草属以鞘翅目为祖先寄主”这一观点或需进一步探讨，暗示该属在早期演化过程中可能经历了寄主转换。O. paraisarioidea 的发现对深入理解线虫草属的起源与早期辐射具有重要意义。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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中国食药用菌物种编目

吴芳, 刘树彬, 王向华, 张明, 杨祝良, 戴玉成
我国食药用菌物种丰富，随着对其分类和系统发育研究的不断深入，物种名称和分类位置不断变化。有些原来在我国有报道的种类经近年的研究发现在中国没有分布，有些种类被发现是复合种，包括了多个隐形种。过去对我国食药用菌物种的报道多以物种名录形式进行列举，对其分类位置和物种组成尚不明确。本文整合近年来最新的研究成果，更新了我国食药用菌物种名录，厘清了物种分类学位置，并提供了各级分类单元的中文名称和拉丁学名，以物种编目的形式进行列举；共记录了我国1 495种食药用菌，隶属于2门、10纲、29目、115科和353属，其中食用菌1 013种，药用菌744种，食药兼用菌262种。本编目中的物种名称中有33.1%为前期名录中未报道或更正的名称。同时，对比分析了我国食用菌和药用菌物种组成情况，发现我国食用菌主要分布在蘑菇纲中蘑菇目(44%)、红菇目(16%)和牛肝菌目(13%)以及盘菌纲的盘菌目(6%)，药用菌主要分布在蘑菇纲的蘑菇目(35%)、多孔菌目(19%)、锈革孔菌目(11%)、红菇目(7%)和牛肝菌目(7%)以及粪壳菌纲的肉座菌目(6%)。数据库(集)基本信息简介数据库(集)名称中国食药用菌物种编目作者吴芳，刘树彬，王向华，张明，杨祝良，戴玉成通信作者杨祝良(fungi@mail.kib.ac.cn)；戴玉成(yuchengdai@bjfu.edu.cn) 数据内容简介数据集整合了近年来最新的研究成果，对我国食药用菌物种名录进行了更新数据产生时间 2019−2025年地理区域地理范围为中国境内文件大小 323 KB 数据量 2门10纲29目115科353属1 495种数据格式 .doc 数据存储地址 ScienceDB数据库 https://cstr.cn/31253.11.sciencedb.jwxb.00003; https://doi.org/10.57760/sciencedb.jwxb.00003"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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中国鸡油菌属物种多样性与地理分布

黄逸秀, 夏文潇, 王科, 邓旺秋, 岳海梅, 张明
鸡油菌属真菌是世界著名食用菌之一，可与松科、壳斗科、桦木科等多种植物形成共生关系，该类群子实层体呈脉络状、脊状或光滑，是研究大型真菌系统发育与进化的关键类群，在大型真菌系统学研究中具有重要地位。我国鸡油菌属真菌物种丰富，记录有83个名称，但这些名称部分存在误用、滥用等现象。本研究在广泛采集标本和资料查阅的基础上，基于形态学与nrLSU、tef1、rpb2和SSU多基因联合系统发育分析，确定我国分布鸡油菌属真菌35种，排除错误鉴定35种，对分布存疑的13个物种进行了分析讨论，并绘制了中国鸡油菌属物种地理分布图，为正确认识中国鸡油菌属真菌物种多样性与地理分布提供重要依据。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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四川九株松树火烧地羊肚菌驯化栽培

王建生, 刘询, 刘天海, 王迪, 余洋, 梁欣敏, 李玉, 何晓兰
对采自四川雅江火烧地的9株野生羊肚菌菌株进行了鉴定和驯化栽培。通过形态学特征及DNA序列分析，确认所有供试菌株均为七妹羊肚菌Morchella eximia。在PDA培养基上，菌株6278菌丝生长速度最快、形成菌核最多，YJ082186生长最慢，6288不形成菌核。依照当前栽培模式进行大田出菇试验，其中6751-1产量最高，达到1.33 kg/m2，6288次之，达到1.31 kg/m2，6288的商品性状最好；YJ082176的出菇密度最大，6283子实体平均大小最大。本研究为进一步七妹羊肚菌新品种选育奠定了基础。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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野生药用真菌光核纤孔菌的生物学特性和抗氧化活性

唐禄鑫, 季盈仪, 刘阳, 王豪, 叶奕萱, 员瑗, 司静
本研究选取广义桑黄类真菌光核纤孔菌Inocutis levis作为研究对象，针对光核纤孔菌在固体培养过程中的生物学特性指标及在液体发酵过程中分泌的多糖、多酚、黄酮、抗坏血酸、超氧化物歧化酶、清除自由基能力以及铁离子还原能力变化进行了测定，证实分离自新疆克拉玛依市小拐乡胡杨林上的野生光核纤孔菌以淀粉、酵母浸粉、KH2PO4、pH 9、35 ℃作为其最适碳源、氮源、无机盐、pH和温度，且具有显著的抗氧化活性(P<0.01)，该研究为今后该种野生药用真菌资源的保护、开发和利用提供了资源储备和基础数据。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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白化卵孢小奥德蘑生物学特性、驯化及抗病性

叶建强, 张芳芳, 陈丽新, 祁亮亮, 蓝桃菊, 刘栩州, 胡永强, 唐军, 韦仕岩, 郎宁
本研究对采自广西乐业县的1株野生白色大型真菌进行了形态学和分子生物学鉴定，确认其为白化卵孢小奥德蘑Oudemansiella raphanipes。通过单因素及正交试验，明确了该菌株菌丝生长的最适碳源、氮源、pH和温度及其最佳组合。其中，最适碳源为果糖，最适浓度为30 g/L，最适氮源为酵母浸粉，最适浓度为8 g/L，最适pH值为8，最适温度为25 ℃，最佳组合为果糖20 g/L、酵母浸粉6 g/L、pH 7.0、温度25 ℃。在栽培试验中，菌株在78%杂木屑的栽培料中，25 d左右完全长满15 cm × 26 cm的栽培袋，经过继续培养20 d左右，出现褐色斑驳现象。该菌株在“菌袋底部割口+倒立”这一不脱袋覆土出菇方式中覆土培养60 d左右，出现了菇蕾，生长4-6 d即可采摘，一般可以采收2潮，每袋平均产量41.83 g，生物学效率16.09%。抗病性实验结果显示，哈茨木霉对该菌株抑制率为33.04%，侵染率为95.55%，表明其属于易感病种类。本研究为白化卵孢小奥德蘑的开发利用提供理论参考。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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甜味小鬼伞生物学特性、驯化栽培及抗氧化活性

赵怡, 康霞, 常光雷, 王立安, 彭慧芬, 田景花, 李守勉, 李国杰
本研究以分离自河北省秦皇岛市青龙县南山公园落叶上腐殖层菌丝获得的甜味小鬼伞Coprinellus saccharinus菌株为试验材料，对生物学特性的4个因素进行了研究，成功培育出子实体，并测定菌丝体和子实体醇提物对ABTS+·和羟自由基的清除能力。结果表明：在生物学特性试验中，甜味小鬼伞菌株的最适碳源是蔗糖和可溶性淀粉，最适氮源是硝酸钾，适宜的pH范围为7-9，在25 ℃条件下菌丝长速最快；在栽培驯化试验中，温度在(20±1)℃条件下菌丝满瓶需要20-25 d，其后给予2-4 ℃温差，保持相对空气湿度70%-80%，12 h/d光周期800-1000 lx散射光，约10-15 d后现原基，2-3 d后子实体成熟。甜味小鬼伞菌丝体与栽培子实体醇提物的抗氧化活性均随添加量的增加逐渐增强，对ABTS+·和羟自由基的清除率均在醇提物添加量为200 μL时达到最高。其中，栽培子实体醇提物的清除率分别为97.93%和67.22%，显著高于菌丝体的相应值(64.73%和24.74%)。菌丝体和栽培子实体醇提物对ABTS+·的清除能力均强于羟自由基，其清除率分别相差39.99%和30.71%。本研究结果为深入探究甜味小鬼伞的栽培技术、生理活性、药理作用及其他开发利用提供了实践依据。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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亚窄孢灵芝中杜松烷型倍半萜及其α-葡萄糖苷酶抑制活性

马世元, 王雨曦, 魏玉莲, 袁海生
本研究聚焦灵芝属物种亚窄孢灵芝Ganoderma subangustisporum的化学成分及其α-葡萄糖苷酶抑制活性分析。从亚窄孢灵芝菌丝体培养物中分离得到2个杜松烷型倍半萜类化合物：17-hydroxy-12-ethoxycarbonyl-α-cadinol (1)和12-hydroxy-α-cadinol (2)。通过高分辨质谱、核磁共振和量子化学计算确定了其结构。其中，化合物1为新化合物，其结构的新颖性在于12位羟基发生了乙酰化。化合物2为首次从灵芝属中分离。化合物1和2均表现出α-葡萄糖苷酶抑制活性，IC50值分别为(96.72±3.87)和(56.82±4.70) μmol/L，分子对接结果揭示化合物1和2主要通过氢键与α-葡萄糖苷酶活性位点的关键氨基酸残基相互作用。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); 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桦褐孔菌的化学成分及抗过敏活性

李海燕, 张慧敏, 陈烜著, 吴峰, 陈维广, 郑永标
桦褐孔菌Inonotus obliquus是一种珍贵的食药用真菌，传统医学中常用于治疗糖尿病、高血脂、肝炎等疾病。为进一步开发桦褐孔菌的功效，作者综合采用溶剂萃取和各种色谱技术(反相硅胶、正相硅胶及凝胶LH-20等)，从桦褐孔菌中分离得到8个化合物，并根据核磁波谱数据，将这些化合物分别鉴定为原儿茶酸(1)、丁香酸(2)、咖啡酸(3)、4-(3,4-二羟苯基)-3-丁烯-2-酮(4)、桦褐孔菌醇(5)、栓菌酸(6)、羊毛甾醇(7)和过氧麦角甾醇(8)。抗过敏活性实验显示，桦褐孔菌醇(5)在4.96、9.92和15.50 μmol/L浓度的脱颗粒率分别为51.03%、30.53%和23.07%，均能显著抑制肥大细胞脱颗粒，具有明显的抗敏舒缓效果。此外，桦褐孔菌醇(5)在15.50 μmol/L浓度以下未表现出明显的细胞毒性，有望用于开发新型抗敏药物。本文研究结果为桦褐孔菌功能性产品开发提供了重要参考。"/>template{display:none;}.mag-rich-xref-fn { cursor: pointer;}//长视频$(document).ready(function(){if($("#showLongArticleVideo") && $("#showLongArticleVideo").length && $("#showLongArticleVideo").length>0){mag_ajax_update({ele_id:'showLongArticleVideo',url:mag_currentQikanUrl() + "/CN/article/showLongArticleVideo.do?id="+$("#articleId").val()});}});//可视化图谱$(document).ready(function(){if($("#showArticle_knowledgeMap") && $("#showArticle_knowledgeMap").length && $("#showArticle_knowledgeMap").length>0){jQuery.getJSON("/Jwxb/CN/lexeme/existsCnctstInArticle.do?articleID="+$("#articleId").val(), null, function(json){if(json.result){$("#showArticle_knowledgeMap").show();}});}});$(document).ready(function(){var metaDataStr = $.trim($("#article_metaJson").val());if(metaDataStr!=''){eval("window.metaData="+metaDataStr);}if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn;}if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en;}var _nlmdtdXml = $("#article_nlmdtdXml").val();var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,'');window.metaData.magDir = magDir;new mag_vue({ el: '#metaVue', //dataUrl: mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do?articleId='+$("#articleId").val(), data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); }, doAfterFun:function(selector,jsonData){doMagVueAfter(selector,jsonData);}});//参考文献可视化richRefCharts(window.metaDatas);var pars = {attachType:'PDF',id:$("#articleId").val(),json:true};jQuery.post($("#mag-common-contextPath").val()+"/CN/article/showArticleFile.do?" + new Date().getTime(), pars, function(data){var json=null;if(data.match(/^\[json\].*/g)){json=eval("("+data.replace(/^\[json\]/g,"")+")");}if(json && json.status == 1){//有权限}else{//无权限$("#no-access-div").show();}});mag_ajax({url:mag_currentQikanUrl() + '/CN/article/getRichHtmlJson.do',data:{articleId:$("#articleId").val(),token:'62d778a598344e3fa8d1131c151f9ef5',referer:document.referrer},dataType:"json",async:"false",success:function(json){if(json.richHtmlJson && json.richHtmlJson.article){if(json.trans){var _nlmdtdXmlCN = $("#article_nlmdtdXmlCN").val();var magDirCN = _nlmdtdXmlCN.replace(/\/[^\/]+$/,'');json.richHtmlJson.magDir=magDirCN;}else{json.richHtmlJson.magDir=magDir;}new mag_vue({ el: '#bodyVue', data:json.richHtmlJson, doTextFun:function(text){ return doDataJsonText(text); 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